Mike Cornell

Mike Cornell

I am a Research Associate in the Information Management Group at the Department of Computer Science, University of Manchester. I am involved in the development of the Genome Information Management System (GIMS). GIMS is an object data warehouse which integrates the yeast genome with functional data.

Background

My original training was as a molecular biologist. After graduation from Thames Polytechnic (now University of Greenwich), I undertook a molocular biology based PhD at University of Leeds. My research involved the identification and characterisation of a Drosophila melangaster ortholog of angiotensin converting enzyme (ACE). ACE is a zinc-metallopeptidase which, in humans, converts angiotensin I to angiotensin II and breaks down bradykinin. It therefore plays an important role in hypertension. This was the first report of an ACE homologue in a non-mammalian species. I continued Drosophila research, working on Suppressor of deltex (Su(dx)) a member of the Notch receptor signalling pathway. My role in this project included the cloning of Su(dx), generation of deletant and UAS and GFP-tagged mutants for expression, analysis of putative Su(dx) mutant strains and identification of possible interacting proteins. In 1998, I made the decision to move into bioinformatics and spent a year looking for evidence of horizontal gene transfer of mobile elements.

Since 1999, I have been responsible for the development of the GIMS database. GIMS is an object data warehouse, which integrates a model of the genome with transcriptome, interactome, metabolic pathway, and annotation data for the budding yeast Saccharomyces cerevisiae. As metabolome and proteome data becomes available this will be incorporated into GIMS. The database has been designed to allow users to ask complex queries across these integrated data sets. In order to allow users remote access to the database, the Online Analysis Environment (OAE), a Java application, has been developed. The OAE can be downloaded here.

Publications:

Cornell, M., Paton, N.W., Hedeler, C., Kirby, P., Delneri, D., Hayes, A. and Oliver, S.G. (2003) GIMS: An integrated data storage and analysis environment for genomic and functional data. Yeast, in press.

Christian Von Mering, Roland Krause, Berend Snel, Michael Cornell, Stephen G. Oliver, Stanley Fields and Peer Bork (2002) Comparative assessment of large-scale data sets of protein–protein interactions. Nature 417: 399 – 403.

Sabine L. Mazaleyrat, Maggy Fostier, Marian B. Wilkin, Hanna Aslam, Dana A.P. Evans, Michael Cornell and Martin Baron (2003) Down-regulation of Notch target gene expression by Suppressor of deltex. Developmental Biology 255: 363-372.

Mike Cornell, Norman W. Paton, Shengli Wu, Carole A. Goble, Crispin J. Miller, Paul Kirby, Karen Eilbeck, Andy Brass, Andrew Hayes and Stephen G. Oliver (2001) GIMS - A Data Warehouse for Storage and Analysis of Genome Sequence and Functional. Data 2nd IEEE International Symposium on Bioinformatics and Bioengineering (BIBE'01) 15-23.

Cornell, M.J., Evans, D.A., Mann, R., Fostier, M., Flasza, M., Monthatong, M., Artavanis-Tsakonas, S. and Baron, M. (1999). The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signalling pathway, is an E3 class ubiquitin ligase. Genetics 152:567-76.

Cornell, M.J., Williams, T.A., Lamango, N.S., Coates, D., Corvol, P., Soubrier, F., Hoheisel, J., Lehrach, H. and Isaac, R.E. (1995). Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster. J Biol Chem. 270:13613-9.

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